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By mouth. For Adult. 2.5 mg, followed by 2.5 mg after at least 2 hours if required, dose to be taken only if migraine recurs, then increased if necessary to 5 mg, dose to be taken only for subsequent attacks in patients not achieving satisfactory relief with 2.5 mg dose; maximum 10 mg per day.
Medscape - Indication-specific dosing for Zomig, Zomig Rapimelt (zolmitriptan), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Bij de behandeling van migraineaanvallen gaat op grond van de bijwerkingen, de voorkeur uit naar paracetamol in voldoende hoge dosering. Tweede keus met een vergelijkbare werkzaamheid maar meer bijwerkingen zijn NSAID's (acetylsalicylzuur, ibuprofen, naproxen) en orale triptanen.
triptanen Werking Werkingsmechanisme Triptanen: activeren selectief de 5HT 1 - receptoragonist, vooral de 5HT 1B - en 5HT 1D-receptoren. Hierdoor komt vasoconstrictie van gedilateerde craniale extracerebrale bloedvaten tot stand.
Compare prices and find information about Triptans prescription drugs. Triptans are used to treat migraines. They constrict blood vessels in the...
Most mammalian species, including humans, have 5-HT 1D binding sites widely distributed throughout the central nervous system. 5-HT 1D receptors are found in all areas of the brain but they differ in quantity at each area. An important initiator of head pain is suggested to be the activation of trigeminovascular afferent nerves which upon ...
Indian Drugs is the scientific publication of the Indian Drugs Manufacturers' Association (IDMA). The journal was started in 1963. Indian Drugs is published monthly and is respected for its peer-reviewed scientific and technical papers.
Combined hormonal contraceptives (containing ethinylestradiol) are predicted to increase the risk of increased ALT concentrations when given with voxilaprevir (with sofosbuvir and velpatasvir).
About Migraine: Migraine headaches are a type of headache that some people get repeatedly over time. Migraines are different from other headaches because they occur with symptoms such as nausea, vomiting, or sensitivity to light.
Il recettore 5-HT1 possiede 5 sottotipi (A, B, D, E, F) tutti accoppiati a proteine G i e proteine G o. Almeno uno dei sottotipi 5-HT1, il recettore 5-HT 1 A, attiva anche un canale al K+ ligando-dipendente e inibisce un canale per il Ca++ voltaggio-dipendente.