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Palifermin (trade name Kepivance, marketed by Biovitrum) is a truncated human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli.KGF stimulates the growth of cells that line the surface of the mouth and intestinal tract.
Palifermin is used to help prevent or heal mouth sores and ulcers in people being treated with chemotherapy and stem cell treatment.. Palifermin is used in people receiving chemotherapy to treat blood cancers (Hodgkin's disease, multiple myeloma, leukemia).palifermin is not a treatment for the cancer itself.
Palifermin is approved to prevent and treat: Oral mucositis that is severe. It is used in patients with leukemia or lymphoma who are being treated with high-dose chemotherapy and radiation therapy, followed by stem cell rescue. Palifermin is also being studied in the treatment of common side effects in other types of cancer.
Palifermin comes as a powder to be mixed with liquid to be injected intravenously (into a vein). It is usually given once a day for 3 days in a row before you receive your chemotherapy treatment and then once a day for 3 days in a row after you receive your chemotherapy for a total of 6 doses.
If you are allergic to palifermin; any part of palifermin; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you are being treated with melphalan. If you are breast-feeding. Do not breast-feed while you take palifermin and for 2 weeks after your last dose.
Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.
KEPIVANCE ® (palifermin) for Injection, for Intravenous Use. DESCRIPTION. Kepivance (palifermin) is a truncated human KGF produced by recombinant DNA technology in E coli.Kepivance is a water soluble, 140 amino acid protein with a molecular weight of 16.3 kilodaltons. It differs from endogenous human KGF in that the first 23 N terminal amino acids have been deleted to improve protein stability.
Palifermin is a manmade form of a human protein that affects growth of cells within the tissues lining your mouth and digestive tract (esophagus, stomach, and intestines).
palifermin: Kepivance Pharmacologic class: Keratinocyte growth factor (KGF) (rDNA origin) Therapeutic class: Biologic and immunologic agent Pregnancy risk category C Action Produced by recombinant DNA technology in Escherichia coli; binds to KGF receptor on cell surface, resulting in epithelial cell proliferation, differentiation, and ...
Kepivance is indicated to decrease the incidence, duration and severity of oral mucositis in adult patients with haematological malignancies receiving myeloablative radiochemotherapy associated with a high incidence of severe mucositis and requiring autologous-haematopoietic-stem-cell support.