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External links. V. P. Komissarenko; I. S. Chelnakova; A. S. Mikosha (1978). "Effect of o,p-dichlorodiphenyldichloroethane and perthane in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs".
Easy-to-read patient leaflet for Mitotane. Includes indications, proper use, special instructions, precautions, and possible side effects.
Mitotane comes as a tablet to take by mouth. It is usually taken three to four times a day. Take mitotane at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Learn about Lysodren (Mitotane) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Mitotane is a unique antineoplastic agent used solely in the therapy of metastatic, unresectable adrenocortical carcinoma. Mitotane has been associated with a high rate of serum enzyme elevation during therapy, but has had limited clinical use and has not been linked to instances of clinically apparent acute liver injury.
Treatment should be initiated and followed by a suitably experienced specialist. Posology. Treatment in adults should be started with 2 - 3 g mitotane per day and increased progressively (e.g. at two-week intervals) until mitotane plasma levels reach the therapeutic window 14 – 20 mg/l.
Chemotherapy Drug Information, Side Effects, Health and Wellness, and Resources for cancer patients and caregivers before, during and after cancer treatment.
Cushing disease is hyperadrenocorticism caused by an ACTH-secreting tumor of the pituitary gland. Clinical signs include polyuria, polydipsia, alopecia, and muscle weakness. A low-dose dexamethasone suppression test is the preferred diagnostic test. Treatment options include medical therapy
Concerning Dr. Bernard Rollin’s reply to the ethical question of September 2012, published in the December 2012 issue of The CVJ (Can Vet J 2012;53:1246). I hesitate to write this because I expect there will be more eloquent counters to Dr. Rollin’s poorly considered commentary on the “Dog
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