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Doxil displayed linear pharmacokinetics over the range of 10 to 20 mg/m 2. Relative to Doxil doses at or below 20 mg/m 2, the pharmacokinetics of total doxorubicin following a 50 mg/m 2 Doxil dose are nonlinear. At this dose, the elimination half-life of Doxil is longer and the clearance lower compared to a 20 mg/m 2 dose.
Doxil (Doxorubicin Liposomal) chemotherapy side effects, how it's given, how it works, precautions and self care tips for treatment of AIDS-related Kaposi's sarcoma, breast, ovarian, and other cancers
Doxil (see below) is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy, or for the treatment of AIDS-related Kaposi's sarcoma. Liposomal form. There is a pegylated (polyethylene glycol coated) liposome-encapsulated
Find patient medical information for Doxil Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
DOXIL is a sterile, translucent, red liposomal dispersion in 10-mL or 30-mL glass, single use vials. Each vial contains 20 mg or 50 mg doxorubicin HCl at a concentration of 2 mg/mL and a pH of 6.5.
Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i) prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano-liposomes; (ii) high and stable remote loading of doxorubicin driven by a transmembrane ammonium sulfate gradient, which also allows for drug release at the tumor; and (iii) having the liposome lipid bilayer in a ...
Doxil: Caelyx (CA) (UK), Doxil, Myocet (UK) Pharmacologic class: Anthracycline Therapeutic class: Antibiotic antineoplastic Pregnancy risk category D FDA Box Warning • Drug may cause cardiotoxicity. Myocardial damage may lead to heart failure and may occur as total cumulative dose (which includes previous use of other anthracyclines or ...
DOXIL exhibits nonlinear pharmacokinetics at 50 mg/m2; therefore, dose adjustments may result in a non-proportional greater change in plasma concentration and exposure to the drug [see Clinical Pharmacology (12.3)]. Patients should be carefully monitored for toxicity.
Doxorubicin Liposomal (Doxil) chemotherapy side effects, how it's given, how it works, precautions and self care tips for treatment of AIDS-related Kaposi's sarcoma, breast and ovarian cancer