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Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa.
Medscape - Indication-specific dosing for Azactam (aztreonam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and ...
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Aztreonam is a monocyclic beta-lactam (‘monobactam’) antibiotic with an antibacterial spectrum limited to Gram-negative aerobic bacteria including Pseudomonas aeruginosa, Neisseria meningitidis, and Haemophilus influenzae; it should not be used alone for ‘blind’ treatment since it is not active against Gram-positive organisms.
Rx only. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for injection and other antibacterial drugs, Aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Aztreonam - Azactam ® The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.
Renal Impairment in Adult Patients. Prolonged serum levels of aztreonam may occur in patients with transient or persistent renal insufficiency. Therefore, the dosage of AZACTAM should be halved in patients with estimated creatinine clearances between 10 mL/min/1.73 m2 and 30 mL/min/1.73 m2 after an initial loading dose of 1 g or 2 g.
Klicken und ziehen, um das 3D-Modell auf der Seite zu verschieben. 3 Wirkmechanismus. Als Betalaktamantibiotikum inhibiert Aztreonam die Zellwandsynthese der Bakterien, indem es an das Penicillin-bindende Protein bindet und dieses mit seinem Lactamring so blockiert, dass die Peptidoglykane der Zellwand nicht miteinander verknüpft werden können.
Official patient website for CAYSTON (aztreonam for inhalation solution). Learn about study results, treatment, dosing, side effects and financial assistance.