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Amifostine was originally indicated to reduce the cumulative renal toxicity from cisplatin in non-small cell lung cancer. However, while nephroprotection was observed, the probability that amifostine could protect tumors could not be excluded. Additional data have shown that amifostine-mediated tumor protection, in any clinical scenario, is ...
If your child has been given amifostine, ask the doctor for information about the benefits and risks. Talk with the doctor if you have questions about giving amifostine to your child. What do I need to tell my doctor BEFORE I take Amifostine? If you have an allergy to amifostine, aminothiol compounds, or any other part of amifostine.
Amifostine is a white crystalline powder which is freely soluble in water. Its empirical formula is C 5 H 15 N 2 O 3 PS and it has a molecular weight of 214.22. Amifostine for Injection is the trihydrate form of Amifostine and is supplied as a sterile lyophilized powder requiring reconstitution for intravenous infusion.
Amifostine is approved to prevent: Renal toxicity. It is used to reduce the nephrotoxic effects caused by repeated treatment with cisplatin for advanced ovarian cancer. Xerostomia (dry mouth). It is used to decrease dryness in the mouth caused by radiation therapy after surgery in some patients with head and neck cancer.
Amifostine comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. When amifostine is used to protect the kidneys against the harmful effects of cisplatin, it is usually given over 15 minutes starting 30 minutes before you receive your chemotherapy treatment.
Amifostine appears to protect the salivary glands from the effects of radiation therapy and may prove to be helpful in preventing or minimizing the effects of xerostomia and the loss of taste. 111,112,114,116,158,159 Several studies have reported significant reduction in the severity of acute and chronic radiation-induced xerostomia with prophylactic use of amifostine, as determined by non ...
Indication: ETHYOL (amifostine) is indicated to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. ETHYOL is indicated to reduce the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer, where the radiation port includes a substantial portion ...
Amifostine is an organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol.A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.It has a role as a prodrug, a radiation protective agent and an antioxidant.
amifostine: [ am″ĭ-fos´tēn ] a chemoprotectant used to prevent renal toxicity in cisplatin chemotherapy and to reduce esophagitis , xerostomia , and loss of taste in patients receiving radiation therapy for head, neck, or lung cancer.